Q) What is the recanalization rate in cerebral venous thrombosis (CVT) after anticoagulation treatment?
A) A systemic review and meta-analysis of 818 patients with CVT showed that the overall rate of recanalization was 85%. The rate of complete recanalization was 49% and the rate of partial recanalization was 35%. The overall recanalization tended to increase with time. By 3 months, three quarters of the patients achieve recanalization.
Clinical predictors of recanalization were female sex, younger age and having an identified etiologic condition for CVT.
There was a significant increase chance of favorable outcomes (mRS, 0-1) in patients with recanalization with a pooled odds ratio of 3.3. It is unclear whether the lack of recanalization should influence the anticoagulation treatment duration, as the evidence of its correlation and CVT recurrence was scarce.
1) Aguiar de Sousa D, Lucas Neto L, Canhão P, Ferro JM. Recanalization in Cerebral Venous Thrombosis. Stroke. 2018;49(8):1828-1835.
2) Leach JL, Wolujewicz M, Strub WM. Partially recanalized chronic dural sinus thrombosis: findings on MR imaging, time-of-flight MR venography, and contrast-enhanced MR venography. AJNR Am J Neuroradiol. 2007;28(4):782-789.